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Ankylosing spondylitis: a risk factor for myocardial infarction?
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  • Published on:
    Re:Ankylosing spondylitis and myocardial infarction: a true association or selection bias?
    • Michael Nurmohamed, rheumatology
    • Other Contributors:
      • M M J Nielen, M J L Peters, R A Verheij

    Dear Editor,

    De Vries and and Abbing-Karahagopian doubt the validity of the outcomes of our study and state that the myocardial infarction (MI) incidence rate in the control population might be underestimated, as they are much lower than rates found by Koek et al.

    However, there seems to be some misunderstanding about what these data represent. Our figures were derived from routine electronic medical records o...

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    Conflict of Interest:
    None declared.
  • Published on:
    Ankylosing spondylitis and myocardial infarction: a true association or selection bias?
    • Frank de Vries, Epidemiologist
    • Other Contributors:
      • Victoria Abbing-Karahagopian

    Dear Editor,

    Dr Peters and co-workers conducted a case-control study, which showed that myocardial infarction (MI) was a 2-3-fold increased in patients with ankylosing spondylitis (AS). They compared AS patients to a sample of the Dutch general population. We are concerned that the association is (largely) explained by inappropriate selection of controls, instead of reflecting a causal pathway [1]. The authors compared...

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    Conflict of Interest:
    None declared.