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No data are available regarding the safety and efficacy of B-cell depletion in the spondyloarthropathies (SpA), except for two case reports. One patient with ankylosing spondylitis (AS) was prescribed rituximab (RTX) for lymphoma without any improvement of the AS.1 One patient with psoriatic arthritis responded to RTX.2
The French Autoimmunity and Rituximab (AIR) registry, prospectively collects data on patients treated with RTX on- and off-label for refractory arthritides by their clinicians.3 On 23 February 2009, 1383 patients with rheumatoid arthritis, 93 with systemic lupus erythematosus, 43 with primary Sjögren’s syndrome, 55 with vasculitis, 30 with myositis and 112 with other autoimmune or inflammatory diseases, had been included in AIR registry. Among the last group …
Funding The French Society of Rheumatology is the promoter of AIR registry. A restricted grant from Roche was allocated for the first 5 years of the AIR registry.
Competing interests None.
Ethics approval Ethics committee approval from the AIR registry.
Patient consent Patient consent received.
Provenance and Peer review Not commissioned; externally peer reviewed.