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Comparison of utility measures and their relationship with other health status measures in 1041 patients with rheumatoid arthritis
  1. Siri Lillegraven1,
  2. Ivar Sønbø Kristiansen2,3,
  3. Tore K Kvien1
  1. 1Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
  2. 2Institute of Health Management and Health Economics, University of Oslo, Oslo, Norway
  3. 3Institute of Public Health, University of Southern Denmark, Odense, Denmark
  1. Correspondence to Siri Lillegraven, Department of Rheumatology, Diakonhjemmet Hospital, Box 23 Vinderen, Oslo N-0319, Norway; siri.lillegraven{at}


Objectives The aim of this study was to compare three health utility instruments (15D, EQ-5D, SF-6D) and a rating scale for health (EQ-Visual Analogue Scale (VAS)) and to investigate their relationship to clinical parameters in patients with rheumatoid arthritis (RA).

Methods Data were collected from 1041 patients with RA. Agreement between the instruments was assessed with Bland–Altman plots. Linear regression models were fitted for the different instruments and Health Assessment Questionnaire (HAQ) scores, age, gender, patient global, disease duration and educational level. Differences in utility scores across levels of global health and disability, were investigated as well as correlations with disease-specific health status measures.

Results The score range in the 1041 patients with RA was 0.41–1.0 for 15D, −0.48 to 1.0 for EQ-5D, 0.0–1.0 for EQ-VAS and 0.30–1.0 for SF-6D, with a bimodal distribution for EQ-5D. Bland–Altman plots indicated poor agreement between EQ-5D and SF-6D/15D and moderate agreement between SF-6D and 15D. Utility scores were correlated with disease-specific measures, pain and fatigue (r>0.60). Mean utilities ranged from 0.30 (EQ-5D) to 0.69 (15D) in patients rating their own health as poor. When correcting for a non-linear relationship between HAQ and EQ-5D/SF-6D in linear regression models, the estimated utilities had non-overlying CI for HAQ values >1.4.

Conclusions Diverging scores were observed across utility instruments, especially in patients with high HAQ scores. The choice of utility instrument may have an impact on the results of cost-utility analyses, with large hypothetical differences in price per quality-adjusted life year.

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  • Competing interests None. The handling editor of this manuscript was Johannes WJ Bijlsma.

  • Funding Abbott provided an unrestricted grant to Diakonhjemmet Hospital corresponding to a 7-month salary for a research fellow (SL). The sponsor had no influence on the design of the study or wording of the manuscript and did not review or comment on the text of this manuscript at any stage of the research process.

  • Ethics approval This study was conducted with the approval of the regional ethics committee and the Data Inspectorate.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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