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Nedd5 is an intracytoplasmic protein of the septin family, expressed on the endothelial cell surface after apoptotic stimuli, thus behaving as an autoantigen in different autoimmune diseases.1 2 Several cellular signalling pathways, acting either in cell cycle regulation or in apoptosis, may be altered by the upregulation of Nedd5 expression.3 4
Anti-Nedd5 autoantibodies are significantly higher in patients with psychiatric lupus erythematosus and in those affected by systemic sclerosis (SSc).5 Considering that the vascular endothelium has a pivotal position in the pathophysiology of SSc, although the great part of factors provoking the endothelial damage remains unknown,6 the aim of this study was to evaluate anti-Nedd5 serum immunoreactivity responses in patients with SSc and to find out whether it can be associated to the different aspects of this …
Competing interests None declared.
Ethics approval Ethics approval was granted by the ethics committee of the Ospedale Policlinico Umberto I of Rome.
Provenance and Peer review Not commissioned; externally peer reviewed.
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