Objective: To analyse the mitochondrial DNA (mtDNA) haplogroups of patients with hip osteoarthritis (OA) and those of healthy controls in a Spanish population.
Methods: mtDNA haplogroups were assigned to 550 cases of hip OA and 505 clinically asymptomatic controls. Sets of controls with healthy knees and hips (n = 179) and patients with knee and/or hip OA (n = 977) were also analysed in a multivariate analysis after adjusting for sex, age and smoking.
Results: Individuals carrying haplogroup J showed a significantly decreased risk of developing hip OA (OR 0.661; 95% CI 0.440 to 0.993; p = 0.045). In addition to haplogroup J, smoking protected against the development of hip OA (OR 0.543; 95% CI 0.311 to 0.946; p = 0.031). However, no relationship was found between rheumatoid arthritis and mtDNA haplogroups.
Conclusion: The results of this study support the hypothesis that the mtDNA haplogroups have a role in the complex osteoarthritic process.
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▸ Additional data are published online only at http://ard.bmj.com/content/vol69/issue1
Funding This study was supported by grants from Fundacion Española de Reumatologia (Proyecto GEN-SER), Instituto de Salud Carlos III (FIS: PI-082028). Secretaría I+D+I Xunta de Galicia (PGIDIT06PXIC916175PN) and from Fondo Investigación Sanitaria (CIBER-BBN CB06/01/0040) Spain, with participation of funds from (FEDER) European Community. IR was supported by Contrato de Apoyo a la Investigación-Fondo Investigación Sanitaria (CA06/01102).
Competing interests None.
Ethics approval Informed consent was obtained from the patients and the study was approved by the ethical committee of the Galician Health Administration.
Provenance and Peer review Not commissioned; externally peer reviewed.