The time has come to limit the placebo period in rheumatoid arthritis trials to 3 months: a systematic comparison of 3- and 6-month response rates in trials of biological agents

M Boers

doi:10.1136/ard.2009.115832

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The time has come to limit the placebo period in rheumatoid arthritis trials to 3 months: a systematic comparison of 3- and 6-month response rates in trials of biological agents

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	Abstract	Full	Pdf
Sep 2009	36	0	24
Oct 2009	58	0	39
Nov 2009	7	0	13
Dec 2009	96	42	56
Jan 2010	55	49	41
Feb 2010	39	14	63
Mar 2010	21	15	28
Apr 2010	29	10	24
May 2010	13	14	25
Jun 2010	12	13	20
Jul 2010	18	19	25
Aug 2010	13	12	11
Sep 2010	37	9	5
Oct 2010	23	53	28
Nov 2010	16	9	16
Dec 2010	6	12	12
Jan 2011	21	8	16
Feb 2011	6	10	18
Mar 2011	12	4	9
Apr 2011	10	3	9
May 2011	7	10	11
Jun 2011	14	7	13
Jul 2011	18	7	9
Aug 2011	23	5	14
Sep 2011	13	7	13
Oct 2011	15	5	10
Nov 2011	18	12	7
Dec 2011	12	8	6
Jan 2012	30	8	20
Feb 2012	25	4	7
Mar 2012	43	6	10
Apr 2012	32	7	11
May 2012	16	6	14
Jun 2012	29	10	12
Jul 2012	33	5	17
Aug 2012	14	6	19
Sep 2012	20	3	8
Oct 2012	16	10	8
Nov 2012	23	16	6
Dec 2012	20	6	8
Jan 2013	30	21	8
Feb 2013	33	11	11
Mar 2013	36	7	10
Apr 2013	22	5	12
May 2013	16	7	16
Jun 2013	13	3	8
Jul 2013	10	3	805
Aug 2013	19	5	8
Sep 2013	13	4	8
Oct 2013	10	8	11
Nov 2013	27	5	16
Dec 2013	8	5	9
Jan 2014	10	2	7
Feb 2014	9	3	5
Mar 2014	28	6	10
Apr 2014	20	6	6
May 2014	17	9	5
Jun 2014	8	6	12
Jul 2014	20	13	7
Aug 2014	5	4	2
Sep 2014	6	4	8
Oct 2014	7	7	8
Nov 2014	7	6	4
Dec 2014	5	1	4
Jan 2015	3	9	8
Feb 2015	7	5	6
Mar 2015	18	4	6
Apr 2015	3	2	2
May 2015	2	4	5
Jun 2015	0	2	2
Jul 2015	8	1	2
Aug 2015	4	4	2
Sep 2015	13	12	5
Oct 2015	4	2	1
Nov 2015	3	4	1
Dec 2015	33	5	4
Jan 2016	9	12	9
Feb 2016	13	10	6
Mar 2016	17	15	13
Apr 2016	22	24	6
May 2016	8	7	4
Jun 2016	7	4	1
Jul 2016	3	3	3
Aug 2016	3	2	13
Sep 2016	15	7	11
Oct 2016	9	3	13
Nov 2016	14	2	6
Dec 2016	8	5	4
Jan 2017	11	7	2
Feb 2017	5	3	2
Mar 2017	4	12	5
Apr 2017	2	18	4
May 2017	0	14	3
Jun 2017	14	13	5
Jul 2017	17	13	1
Aug 2017	37	23	2
Sep 2017	33	19	3
Oct 2017	43	13	5
Nov 2017	35	17	1
Dec 2017	7	7	1
Jan 2018	25	21	0
Feb 2018	24	18	1
Mar 2018	20	18	3
Apr 2018	16	10	2
May 2018	22	11	4
Jun 2018	16	8	4
Jul 2018	16	6	3
Aug 2018	8	6	1
Sep 2018	12	12	0
Oct 2018	13	7	2
Nov 2018	12	12	1
Dec 2018	7	7	1
Jan 2019	6	6	2
Feb 2019	7	7	4
Mar 2019	6	6	2
Apr 2019	4	4	4
May 2019	5	5	4
Jun 2019	8	7	17
Jul 2019	6	4	7
Aug 2019	11	11	5
Sep 2019	4	4	1
Oct 2019	9	9	6
Nov 2019	26	26	2
Dec 2019	14	14	3
Jan 2020	19	19	6
Feb 2020	4	4	3
Mar 2020	3	3	6
Apr 2020	4	4	2
May 2020	9	9	1
Jun 2020	14	14	11
Jul 2020	10	9	4
Aug 2020	4	4	5
Sep 2020	13	9	3
Oct 2020	14	12	11
Nov 2020	10	7	5
Dec 2020	12	11	2
Jan 2021	7	7	3
Feb 2021	6	6	7
Mar 2021	9	9	8
Apr 2021	5	5	6
May 2021	11	11	8
Jun 2021	4	4	6
Jul 2021	8	8	3
Aug 2021	9	9	13
Sep 2021	13	13	5
Oct 2021	11	10	16
Nov 2021	18	18	23
Dec 2021	16	14	6
Jan 2022	14	15	7
Feb 2022	17	18	6
Mar 2022	19	17	14
Apr 2022	20	16	2
May 2022	23	22	12
Jun 2022	20	20	6
Jul 2022	16	16	4
Aug 2022	22	22	2
Sep 2022	26	26	9
Oct 2022	24	24	4
Nov 2022	11	11	9
Dec 2022	5	3	2
Jan 2023	7	6	3
Feb 2023	30	30	1
Mar 2023	5	5	3
Apr 2023	3	3	11
May 2023	7	7	6
Jun 2023	13	13	5
Jul 2023	8	8	6
Aug 2023	7	7	4
Sep 2023	8	8	4
Oct 2023	10	10	0
Nov 2023	14	13	4
Dec 2023	22	20	6
Jan 2024	3	3	2
Feb 2024	3	3	2
Mar 2024	8	8	45
Total	2657	1714	2293

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