Article Text

Download PDFPDF
Opposite relationships between circulating Dkk-1 and cartilage breakdown in patients with rheumatoid arthritis and knee osteoarthritis
  1. N Voorzanger-Rousselot1,
  2. N Charni Ben-Tabassi1,
  3. P Garnero1,2
  1. 1
    Molecular Markers, CCBR-SYNARC, Lyon, France
  2. 2
    INSERM Research Unit 664, Lyon, France
  1. Correspondence to Dr P Garnero, CCBR-SYNARC, 16 rue Montbrillant, 69003 Lyon, France; patrick.garnero{at}

Statistics from

Recent animal and clinical studies have suggested that Dkk-1, a secreted inhibitor of the canonical Wnt signalling pathway, could play an important role in mediating the alterations of joint tissue turnover associated with rheumatoid arthritis (RA) and osteoarthritis. Diarra et al1 showed that blockage of Dkk-1 abolished bone erosion in an inflammatory mouse model and that circulating Dkk-1 was increased in patients with active RA. More recently, we reported that increased Dkk-1 was associated with a higher risk of radiological bone erosion in patients with early RA receiving anti-tumour necrosis factor therapy.2 On the other hand, elevated circulating levels of Dkk-1 were reported to be moderately associated with reduced radiological progression of hip osteoarthritis in one study …

View Full Text


  • Competing interests None.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.