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Extended report
CHECK (Cohort Hip and Cohort Knee): similarities and differences with the Osteoarthritis Initiative
  1. J Wesseling1,
  2. J Dekker2,
  3. W B van den Berg3,
  4. S M A Bierma-Zeinstra4,
  5. M Boers2,
  6. H A Cats5,
  7. P Deckers6,
  8. K J Gorter1,
  9. P H T G Heuts7,
  10. W K H A Hilberdink8,
  11. M Kloppenburg9,
  12. R G H H Nelissen9,
  13. F G J Oosterveld10,
  14. J C M Oostveen11,
  15. L D Roorda12,
  16. M A Viergever1,
  17. S ten Wolde13,
  18. F P J G Lafeber1,
  19. J W J Bijlsma1
  1. 1
    University Medical Center Utrecht, Utrecht, The Netherlands
  2. 2
    VU University Medical Center, Amsterdam, The Netherlands
  3. 3
    Radboud University Medical Center, Nijmegen, The Netherlands
  4. 4
    Erasmus Medical Center, Rotterdam, The Netherlands
  5. 5
    St Maartenskliniek, Nijmegen, The Netherlands
  6. 6
    Academic Hospital Maastricht, Maastricht, The Netherlands
  7. 7
    Rehabilitation Center Leijpark, Tilburg, The Netherlands
  8. 8
    Allied Health Care Center for Rheumatology and Rehabilitation, Groningen, The Netherlands
  9. 9
    Leiden University Medical Center, Leiden, The Netherlands
  10. 10
    Saxion University of Applied Sciences, Enschede, The Netherlands
  11. 11
    Twenteborg Hospital, Almelo, The Netherlands
  12. 12
    Jan van Breemen Institute, Amsterdam, The Netherlands
  13. 13
    Kennemer Gasthuis Haarlem, Haarlem, The Netherlands
  1. Correspondence to Ms J Wesseling, University Medical Center Utrecht, Department of Rheumatology and Clinical Immunology (F02.127), PO Box 85500, 3508 GA Utrecht, The Netherlands; j.wesseling{at}


Objective: To describe the osteoarthritis study population of CHECK (Cohort Hip and Cohort Knee) in comparison with relevant selections of the study population of the Osteoarthritis Initiative (OAI) based on clinical status and radiographic parameters.

Methods: In The Netherlands a prospective 10-year follow-up study was initiated by the Dutch Arthritis Association on participants with early osteoarthritis-related complaints of hip and/or knee: CHECK. In parallel in the USA an observational 4-year follow-up study, the OAI, was started by the National Institutes of Health, on patients with or at risk of symptomatic knee osteoarthritis. For comparison with CHECK, the entire cohort and a subgroup of individuals excluding those with exclusively hip pain were compared with relevant subpopulations of the OAI.

Results: At baseline, CHECK included 1002 participants with in general similar characteristics as described for the OAI. However, significantly fewer individuals in CHECK had radiographic knee osteoarthritis at baseline when compared with the OAI (p<0.001). In contrast, at baseline, the CHECK cohort reported higher scores on pain, stiffness and functional disability (Western Ontario and McMaster osteoarthritis index) when compared with the OAI (all p<0.001). These differences were supported by physical health status in contrast to mental health (Short Form 36/12) was at baseline significantly worse for the CHECK participants (p<0.001).

Conclusion: Although both cohorts focus on the early phase of osteoarthritis, they differ significantly with respect to structural (radiographic) and clinical (health status) characteristics, CHECK expectedly representing participants in an even earlier phase of disease.

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  • Funding CHECK is funded by the Dutch Arthritis Association on the lead of a steering committee comprising 16 members with expertise in different fields of osteoarthritis chaired by JWJB and coordinated by JW. Involved are: Academic Hospital Maastricht; Erasmus Medical Center Rotterdam; Jan van Breemen Institute/VU Medical Center Amsterdam; Kennemer Gasthuis Haarlem; Martini Hospital Groningen/Allied Health Care Center for Rheumatology and Rehabilitation Groningen; Medical Spectrum Twente Enschede/Twenteborg Hospital Almelo; St Maartenskliniek Nijmegen; Leiden University Medical Center; University Medical Center Utrecht and Wilhelmina Hospital Assen.

  • Competing interests None.

  • Ethics approval The study was approved by the medical ethics committees of all participating centres.

  • Patient consent Obtained.

  • The OAI is a public–private partnership comprised of five contracts (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health (NIH) and conducted by the OAI study investigators. This paper was prepared using an OAI public use dataset and does not necessarily reflect the opinions or views of the OAI investigators, the NIH, or the private funding partners.

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