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Optimalisation of the clinical pharmacogenetic model to predict methotrexate treatment response: the influence of the number of haplotypes of MTHFR 1298A–677C alleles on probability to respond

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  • Competing interests: None.

  • Funding: The Foundation Nuts Ohra (Amsterdam) and Schering-Plough BV contributed to this work financially.

  • Ethics approval: Ethics approval was obtained from Leiden University Medical Centre, Leiden, The Netherlands.

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