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Several single nucleotide polymorphisms (SNP) have been reported to be associated with the efficacy of methotrexate in the treatment of rheumatoid arthritis (RA).1 2 Subsequently, we developed a clinical model to predict the efficacy of methotrexate monotherapy in patients with recent-onset RA (N = 205).3 The model consists of non-genetic factors, sex, rheumatoid factor and smoking status, disease activity score (DAS) before starting methotrexate and four genetic polymorphisms (MTHFD1 1958G>A, AMPD1 34C>T, ITPA 94A>C and ATIC 347C>G). Associations of these factors with the response to methotrexate were transformed into a scoring system ranging from 0 to 11.5 points. The predictive model showed a positive predictive value of 95% and a negative predictive value of 86% and was able to categorise 60% of …
Competing interests: None.
Funding: The Foundation Nuts Ohra (Amsterdam) and Schering-Plough BV contributed to this work financially.
Ethics approval: Ethics approval was obtained from Leiden University Medical Centre, Leiden, The Netherlands.
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