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Genetic factors are hypothesised to play a role in the susceptibility to antiphospholipid syndrome (APS) based on several family studies in patients with anti-phospholipid antibodies (aPL) and/or clinical manifestations of APS. APS can occur alone (primary APS) or in conjunction with systemic lupus erythematosus (SLE). Therefore, APS and SLE may, in part, share a common mechanism for disease onset or progression. Likewise SLE, human leukocyte antigen (HLA) associations have been reported in APS.1 In addition, polymorphisms of target antigens for aPL and thrombotic genetic risk factors have been described.1 Despite the numerous studies on the immunogenetic predisposition to APS, only a few genes …
Competing interests: None declared.
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