Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research

C Salliot; D van der Heijde

doi:10.1136/ard.2008.093690

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Clinical and epidemiological research

Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research

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	Abstract	Full	Pdf
Dec 2008	276	0	228
Jan 2009	120	0	185
Feb 2009	35	0	135
Mar 2009	25	0	135
Apr 2009	33	0	123
May 2009	21	0	81
Jun 2009	190	103	270
Jul 2009	229	271	339
Aug 2009	719	194	252
Sep 2009	148	111	164
Oct 2009	58	115	78
Nov 2009	54	92	95
Dec 2009	44	59	70
Jan 2010	57	97	81
Feb 2010	62	100	86
Mar 2010	42	73	86
Apr 2010	47	94	106
May 2010	66	101	87
Jun 2010	43	70	49
Jul 2010	22	59	54
Aug 2010	42	88	63
Sep 2010	84	113	62
Oct 2010	75	107	73
Nov 2010	59	71	56
Dec 2010	45	98	43
Jan 2011	50	60	55
Feb 2011	42	85	62
Mar 2011	69	71	58
Apr 2011	73	64	74
May 2011	42	64	74
Jun 2011	35	58	83
Jul 2011	63	77	74
Aug 2011	65	104	66
Sep 2011	54	120	59
Oct 2011	81	102	57
Nov 2011	110	85	67
Dec 2011	106	81	68
Jan 2012	109	72	40
Feb 2012	118	67	58
Mar 2012	136	75	60
Apr 2012	132	81	72
May 2012	132	106	57
Jun 2012	123	73	51
Jul 2012	122	59	53
Aug 2012	141	48	55
Sep 2012	116	52	46
Oct 2012	169	70	75
Nov 2012	132	90	61
Dec 2012	99	43	33
Jan 2013	128	69	50
Feb 2013	118	48	54
Mar 2013	109	90	74
Apr 2013	145	130	89
May 2013	114	133	81
Jun 2013	97	118	94
Jul 2013	116	116	82
Aug 2013	124	111	37
Sep 2013	140	98	71
Oct 2013	141	145	60
Nov 2013	157	182	72
Dec 2013	103	108	41
Jan 2014	118	141	62
Feb 2014	95	156	58
Mar 2014	119	244	67
Apr 2014	109	163	51
May 2014	132	215	55
Jun 2014	108	229	50
Jul 2014	120	251	58
Aug 2014	99	198	39
Sep 2014	100	261	55
Oct 2014	100	178	54
Nov 2014	94	214	47
Dec 2014	59	149	32
Jan 2015	73	240	60
Feb 2015	87	189	50
Mar 2015	58	200	40
Apr 2015	81	188	59
May 2015	66	225	36
Jun 2015	68	214	39
Jul 2015	79	230	47
Aug 2015	56	218	36
Sep 2015	143	194	31
Oct 2015	63	133	30
Nov 2015	64	180	29
Dec 2015	80	175	32
Jan 2016	91	243	45
Feb 2016	58	182	33
Mar 2016	110	205	58
Apr 2016	70	208	46
May 2016	91	197	58
Jun 2016	76	186	70
Jul 2016	73	147	67
Aug 2016	79	166	47
Sep 2016	111	201	31
Oct 2016	91	176	51
Nov 2016	127	213	54
Dec 2016	127	174	36
Jan 2017	128	241	57
Feb 2017	23	160	65
Mar 2017	55	300	62
Apr 2017	51	461	58
May 2017	43	510	47
Jun 2017	144	428	44
Jul 2017	569	511	38
Aug 2017	714	627	45
Sep 2017	620	518	48
Oct 2017	648	544	38
Nov 2017	677	619	48
Dec 2017	470	404	33
Jan 2018	689	589	66
Feb 2018	626	540	47
Mar 2018	580	468	37
Apr 2018	447	395	40
May 2018	265	229	25
Jun 2018	541	538	25
Jul 2018	541	471	38
Aug 2018	516	490	37
Sep 2018	615	525	37
Oct 2018	720	712	42
Nov 2018	645	645	32
Dec 2018	505	505	38
Jan 2019	654	653	43
Feb 2019	591	574	36
Mar 2019	704	649	85
Apr 2019	676	652	50
May 2019	668	664	48
Jun 2019	513	513	33
Jul 2019	524	526	44
Aug 2019	475	472	50
Sep 2019	448	449	34
Oct 2019	488	485	45
Nov 2019	459	456	47
Dec 2019	373	372	32
Jan 2020	433	432	42
Feb 2020	390	388	54
Mar 2020	387	386	59
Apr 2020	229	229	39
May 2020	198	198	61
Jun 2020	178	178	70
Jul 2020	146	146	40
Aug 2020	219	213	38
Sep 2020	244	244	70
Oct 2020	255	253	61
Nov 2020	289	289	70
Dec 2020	285	283	47
Jan 2021	372	370	63
Feb 2021	306	306	45
Mar 2021	360	359	103
Apr 2021	299	297	57
May 2021	330	330	50
Jun 2021	307	307	79
Jul 2021	303	303	64
Aug 2021	341	341	48
Sep 2021	376	375	61
Oct 2021	364	362	83
Nov 2021	318	317	77
Dec 2021	232	234	41
Jan 2022	288	317	76
Feb 2022	388	395	54
Mar 2022	347	351	92
Apr 2022	468	473	64
May 2022	243	257	69
Jun 2022	283	281	43
Jul 2022	255	258	48
Aug 2022	272	268	52
Sep 2022	255	262	51
Oct 2022	256	259	43
Nov 2022	251	252	36
Dec 2022	191	187	32
Jan 2023	252	253	42
Feb 2023	287	287	41
Mar 2023	251	250	53
Apr 2023	183	185	35
May 2023	227	226	51
Jun 2023	162	162	30
Jul 2023	169	167	39
Aug 2023	141	140	29
Sep 2023	160	160	51
Oct 2023	218	217	39
Nov 2023	283	282	43
Total	40078	43178	11106

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