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Competing interests: Declared. MØ has received consulting fees, speaking fees and/or research grants from Abbott, Amgen, Bristol-Myers Squibb, Centocor, Genmab, Glaxo-SmithKline, Leo Pharma, Novartis, Novo, Pfizer, Roche, Schering-Plough, UCB-Nordic and Wyeth. MSH has received consulting fees, speaking fees and/or research grants from Bristol-Myers Squibb, Roche, Schering-Plough and Wyeth.
Funding: Roche Denmark gave financial support but had no influence on the planning, analysis or manuscript preparation.
Ethics approval: The study had local ethics committee approval and followed the Declaration of Helsinki.
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