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One year change of knee cartilage morphology in the first release of participants from the Osteoarthritis Initiative progression subcohort: association with sex, body mass index, symptoms and radiographic osteoarthritis status
  1. F Eckstein1,
  2. S Maschek2,
  3. W Wirth2,
  4. M Hudelmaier1,
  5. W Hitzl3,
  6. B Wyman4,
  7. M Nevitt5,
  8. M-P Hellio Le Graverand4,
  9. the OAI Investigator Group
  1. 1
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
  2. 2
    Chondrometrics GmbH, Ainring, Germany
  3. 3
    Research Office, Paracelsus Medical University, Salzburg, Austria
  4. 4
    Pfizer Global Research and Development, New London, Connecticut, USA
  5. 5
    University of California and OAI Coordinating Center, San Francisco, California, USA
  1. Professor F Eckstein, Institute of Anatomy and Musculoskeletal Research, PMU, Strubergasse 21, A5020 Salzburg, Austria; felix.Eckstein{at}


Objective: The Osteoarthritis Initiative (OAI) is a multicentre study targeted at identifying biomarkers for evaluating the progression and risk factors of symptomatic knee OA. Here cartilage loss using 3 Tesla (3 T) MRI is analysed over 1 year in a subset of the OAI, together with its association with various risk factors.

Methods: An age- and gender-stratified subsample of the OAI progression subcohort (79 women and 77 men, mean (SD) age 60.9 (9.9) years, body mass index (BMI) 30.3 (4.7)) with both frequent symptoms and radiographic OA in at least one knee was studied. Coronal FLASHwe (fast low angle shot with water excitation) MRIs of the right knee were acquired at 3 T. Seven readers segmented tibial and femoral cartilages blinded to order of acquisition. Segmentations were quality controlled by one expert.

Results: The reduction in mean cartilage thickness (ThC) was greater (p = 0.004) in the medial than in the lateral compartment, greater (p = 0.001) in the medial femur (−1.9%) than in the medial tibia (−0.5%) and greater (p = 0.011) in the lateral tibia (−0.7%) than in the lateral femur (0.1%). Multifactorial analysis of variance did not reveal significant differences in the rate of change in ThC by sex, BMI, symptoms and radiographic knee OA status. Knees with Kellgren–Lawrence grade 2 or 3 and with a BMI >30 tended to display greater changes.

Conclusions: In this sample of the OAI progression subcohort, the greatest, but overall very modest, rate of cartilage loss was observed in the weight-bearing medial femoral condyle. Knees with radiographic OA in obese participants showed trends towards higher rates of change than those of other participants, but these trends did not reach statistical significance.

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  • Competing interests: FE is CEO of Chondometrics GmbH, a company providing MR image analysis services. He provides consulting services to Pfizer, MerckSerono, Wyeth and Novo Nordisk. SM, WM and MH have part-time appointments with Chondometrics GmbH. BW and M-PH are employed by Pfizer Inc.

  • Funding: Data acquisition: Osteoarthritis Initiative. Image analysis: Pfizer Inc.

  • Ethics approval: The study was conducted in compliance with the ethical principles derived from the Declaration of Helsinki and in compliance with local Institutional Review Board, informed consent regulations and International Conference on Harmonization Good Clinical Practices Guidelines.