Article Text

Download PDFPDF
Lymph node IL-18 expression in adult-onset Still’s disease
  1. P Conigliaro1,3,
  2. R Priori1,
  3. M Bombardieri2,
  4. C Alessandri1,
  5. F Barone1,2,
  6. C Pitzalis2,
  7. I B McInnes3,
  8. G Valesini1
  1. 1
    Cattedra Di Reumatologia, Dipartimento di Clinica e Terapia Medica, Sapienza Università di Roma, Rome, Italy
  2. 2
    Rheumatology Department, GKT School of Medicine, King’s College, London, UK
  3. 3
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
  1. Professor G Valesini, Dipartimento di Clinica e Terapia Medica, Cattedra di Reumatologia, Sapienza Università di Roma, V le del Policlinico 155, 00161 Roma, Italy; guido.valesini{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

IL-18 is a pleiotropic immunoregulatory cytokine that has been described and implicated in the pathogenesis of a variety of inflammatory diseases.14

Studies in murine models of arthritis and clinical studies suggest that dendritic cells, macrophages and synoviocites within the synovial membrane can produce IL-18.1 57 IL-18 expression has in turn been implicated in the reciprocal regulation of other pro-inflammatory cytokines, such as tumour necrosis factor alpha.8

Recent data clearly demonstrated that IL-18 serum levels were significantly elevated in adult-onset Still’s disease (AOSD) and correlated with disease activity and serum ferritin levels.24 AOSD is characterised by substantial and dysregulated …

View Full Text


  • Competing interests: None.

  • Funding: PC is receiving fellowship support from the University of Glasgow. MB is receiving support from the Arthritis Research Campaign.