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Systemic juvenile idiopathic arthritis (sJIA) is characterised by systemic inflammatory symptoms such as spiking fever, skin rash, pericarditis and hepatosplenomegaly, along with arthritis.1 We reported the abnormal expression of genes involved in cytokine networks and mitochondrial function in patients with sJIA identified by DNA microarray.2 The current study was performed to extend these results.
To identify genes that correlate with arthritis severity or systemic inflammation in patients with sJIA, we further analysed the 3491 genes identified by prior microarray analysis to be abnormally expressed in the peripheral blood of 51 patients with sJIA.2 They all fulfilled International League of Associations for Rheumatology (ILAR) criteria.3 Of these …
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