Objective: To analyse associations between the clinical status of patients with rheumatoid arthritis (RA) and the gross domestic product (GDP) of their resident country.
Methods: The Quantitative Standard Monitoring of Patients with Rheumatoid Arthritis (QUEST–RA) cohort includes clinical and questionnaire data from 6004 patients who were seen in usual care at 70 rheumatology clinics in 25 countries as of April 2008, including 18 European countries. Demographic variables, clinical characteristics, RA disease activity measures, including the disease activity score in 28 joints (DAS28), and treatment-related variables were analysed according to GDP per capita, including 14 “high GDP” countries with GDP per capita greater than US$24 000 and 11 “low GDP” countries with GDP per capita less than US$11 000.
Results: Disease activity DAS28 ranged between 3.1 and 6.0 among the 25 countries and was significantly associated with GDP (r = −0.78, 95% CI −0.56 to −0.90, r2 = 61%). Disease activity levels differed substantially between “high GDP” and “low GDP” countries at much greater levels than according to whether patients were currently taking or not taking methotrexate, prednisone and/or biological agents.
Conclusions: The clinical status of patients with RA was correlated significantly with GDP among 25 mostly European countries according to all disease measures, associated only modestly with the current use of antirheumatic medications. The burden of arthritis appears substantially greater in “low GDP” than in “high GDP” countries. These findings may alert healthcare professionals and designers of health policy towards improving the clinical status of patients with RA in all countries.
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Review history and Supplementary material
A supplemental file of QUEST-RA collaborators is published online only at http://ard.bmj.com/content/vol68/issue11
Funding TS has received grants from Central Finland Health Care District and Heinola Rheumatism Foundation Hospital (EVO grants). Funding sources did not participate in the study design and the collection, management, analysis and interpretation of data, and preparation, review, or approval of the manuscript and the decision to submit it for publication.
Competing interests None.
Provenance and peer review Not commissioned; externally peer reviewed.
Patient consent Obtained.
Contributors Study design: TS, TP, HK. Acquisition of data: The entire QUEST–RA study group. Analyses and interpretation of data: TS, HK, TP. Preparation of the manuscript and approval of the final version: The entire QUEST–RA study group. All researchers had access to all the data. TS takes responsibility for the integrity of the data and the accuracy of the data analysis.
Ethics approval The study was carried out in compliance with the Helsinki Declaration. Ethics Committees or Internal Review Boards of participating institutes approved the study.
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