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The effectiveness of leflunomide as a co-therapy of tumour necrosis factor inhibitors in rheumatoid arthritis: a population-based study
  1. A Finckh1,
  2. S Dehler2,
  3. C Gabay1
  1. 1
    Department of Medicine, Division of Rheumatology, Geneva University Hospital, Geneva, Switzerland
  2. 2
    SCQM Foundation, Department of Social and Preventive Medicine, University of Zurich, Switzerland
  1. Dr A Finckh/Dr C Gabay, Division of Rheumatology, Department of Internal Medicine, University Hospital of Geneva, 26 Av. Beau-Sejour, 1211 Geneva 14. Switzerland; axel.finckh{at} or cem.gabay{at}


Background: Randomised trials have demonstrated that the efficacy of anti-tumour necrosis factor (TNF) agents is significantly increased by concomitant methotrexate (MTX) in rheumatoid arthritis (RA). In clinical routine, anti-TNF agents are commonly prescribed with other disease-modifying antirheumatic drugs (DMARDs) than MTX, however their effectiveness in combination with anti-TNF agents is not well established.

Objective: To compare the effectiveness of leflunomide (LEF) and other conventional DMARDs with MTX as co-therapy to anti-TNF agents in RA.

Methods: All patients on anti-TNF agents and conventional DMARDs within the Swiss Clinical Quality Management (SCQM)-RA database were included (n = 1218) and categorised according to the type of co-therapy into anti-TNF+MTX (n = 842), anti-TNF+LEF (n = 260) and anti-TNF+other DMARDs (n = 116). Drug discontinuation rates and incidence of toxic side effects were analysed using Cox proportional hazard models. Progression of radiographic damage, the evolution of functional disability and the improvement of RA disease activity were analysed using longitudinal regression models, adjusting for potential confounders.

Results: The overall discontinuation rates of anti-TNF and conventional DMARD combination therapies were relatively high with a median survival of only 16 months (interquartile range (IQR): 10–37), but they did not differ between the three regimens (p = 0.69). The progression of radiographic damage (p = 0.77), functional disability (p = 0.09) and RA disease activity (p = 0.33) were also similar between the different regimen. In addition, no significant difference in the frequency of adverse events emerged.

Conclusion: Overall these results suggest that LEF and potentially other conventional DMARDs offer an effective and safe alternative to MTX as co-therapy in combination with anti-TNF agents.

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  • Competing interests: None declared.

  • Funding: AF was funded by a research grant from the Geneva University. SD was funded by the SCQM Foundation. CG by the Swiss National Science Foundation (Grant no. 320000-107592). This study was further partially supported by an unrestricted research grant from Sanofi-Aventis. The SCQM Foundation has received grants from the Swiss Health authorities (BAG), the Swiss Academy for Medical Sciences (SAMW), the JL Warnery Foundation, the Swiss Society of polyarthritic patients (SPV) and pharmaceutical companies (Abbott, Essex, Wyeth, Roche, Bristol-Myers Squibb, Mepha, Novartis, Sanofi-Aventis).