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The Glu228Ala polymorphism in the ligand-binding domain of death receptor 4 is not associated with rheumatoid arthritis
  1. B Yazdani-Biuki1,
  2. K Brickmann1,
  3. U Langsenlehner2,
  4. W Renner3,
  5. M Truschnig3,
  6. P Krippl2,
  7. F Fürst1,
  8. W B Graninger1,
  9. H-P Brezinschek1
  1. 1
    Department of Internal Medicine, Division of Rheumatology, Medical University of Graz, Austria
  2. 2
    General Hospital Fürstenfeld, Department of Internal Medicine, Austria
  3. 3
    Clinical Institute of Medical and Laboratory Diagnostics, Medical University of Graz, Austria
  1. Dr H-P Brezinschek, Department of Internal Medicine, Division of Rheumatology, Medical University of Graz, Auenbruggerplatz 32, 8036 Graz, Austria; hans-peter.brezinsek{at}

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Rheumatoid arthritis (RA) is a chronic inflammatory disease resulting in inflammation of the synovial lining and destruction of the adjacent bone and cartilage. Although the initiating event of RA is still unknown, recent research has demonstrated the importance of the increased production of tumour necrosis factor (TNF) α in the perpetuation of the inflammatory process of this disease. Targeting this molecule with soluble receptors—that is, etanercept, or antibodies, like infliximab or adalimumab, a new class of highly effective antirheumatic drugs has been developed. Unfortunately, not all patients respond sufficiently to TNF blockade or become unresponsive, and therefore …

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  • Competing interests: None declared.

  • Funding: Supported in part by a grant of the Austrian Society for Research and Treatment of Immunological and Rheumatological Diseases.

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