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Prevalence and significance of isotypes of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis
  1. R H Syed,
  2. B E Gilliam,
  3. T L Moore
  1. Division of Adult and Pediatric Rheumatology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
  1. R H Syed, Room 213A Doisy Hall, 1402 S Grand Blvd, Saint Louis, MO 63104, USA; reema_syed{at}

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Several studies have evaluated the potential role for IgG anti-cyclic citrullinated peptide (anti-CCP) antibodies in juvenile idiopathic arthritis (JIA) concerning diagnosis and disease outcome.16 Unlike rheumatoid arthritis (RA),7 8 no study in JIA has evaluated the distribution of anti-CCP antibody isotypes and assessed their significance in the disease process.

We assessed anti-CCP antibody isotype distribution in 72 consecutive patients with JIA (59 female and 13 male), including 14 with IgM RF-positive polyarthritis, 24 with IgM rheumatoid factor (RF)-negative polyarthritis, 21 with oligoarthritis, 11 with systemic-onset arthritis, and 2 with psoriatic arthritis. The mean (SD) age was 12.1 (5.8) years and mean disease duration was 4.8 (4.5) years. The levels of anti-CCP antibody isotypes were measured …

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  • Competing interests: None declared.

  • Funding: Funding was provided by the Campbell-Avery Charitable Trust, the Dorr Family Charitable Trust, and the Lupus/Juvenile Arthritis Research Group of Saint Louis.

  • RHS and BEG contributed equally to this work.

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