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Anti-PDGFR-α antibodies measured by non-bioactivity assays are not specific for systemic sclerosis
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  • Published on:
    Autoantibodies to PDGF receptor and systemic sclerosis

    Dear Editor,

    While the debate on the existence of autoantibodies against the PDGF receptor is amplified by two publications (1, 2) that contradict the data published by Gabrielli and colleagues (3), we wish to point to one important detail in the paper of Balada et al (4).

    The protein that is sold by Upstate biologicals (now Millipore) and was used in the assay developed by Balada and colleagues corresponds to t...

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    Conflict of Interest:
    None declared.
  • Published on:
    Stimulatory autoantibodies against PDGF receptor in scleroderma

    Dear Editor,

    We read with interest the work by Balada et al. publishedin Ann Rheum Dis 2008 Feb 13; [Epub ahead of print].

    Although we noticed the authors pointed out in the title and along the text that anti-PDGFR antibodies in their study were detected by non-functional assays, we thought necessary a comment on their findings, for a better understanding of the subject, mainly for those readers who may n...

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    Conflict of Interest:
    None declared.