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Behçet’s disease (BD) is a multisystemic inflammatory disorder characterised by recurrent ocular symptoms, oral and genital ulcers, and skin lesions.1 2 The aetiology of BD remains unclear, but likely both genetic and environmental factors play an important part in BD development.
We performed a whole-genome association analysis of BD using 23 465 microsatellite markers and ultimately found significant association for 147 markers (unpublished data). One of the 147 markers is located within 100 kb from the toll-like receptor (TLR) 4 gene on chromosome 9. Among the TLR family members, TLR4 is the receptor most exhaustively investigated and has been shown to recognise and interact with heat shock protein (HSP) and …
Funding: This study was supported by grants-in-aid from the Ministry of Education, Science, Sports and Culture of Japan, a grant from the Ministry of Health, Labour and Welfare, Japan, and a grant from the Johnson & Johnson KK Vision Care Company.
Competing interests: None.
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