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Visfatin (pre-B cell colony-enhancing factor) gene expression in patients with rheumatoid arthritis
  1. H Matsui,
  2. A Tsutsumi,
  3. M Sugihara,
  4. T Suzuki,
  5. K Iwanami,
  6. M Kohno,
  7. D Goto,
  8. I Matsumoto,
  9. S Ito,
  10. T Sumida
  1. Division of Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan
  1. A Tsutsumi, Division of Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Ibaraki, Japan; atsutsum{at}md.tsukuba.ac.jp

http://dx.doi.org/10.1136/ard.2007.077578

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    Visfatin, also known as pre-B cell colony enhancing factor, is a cytokine-like protein originally cloned from peripheral blood mononuclear cells (PBMC) as a factor that enhances differentiation of pre-B cells in synergy with interleukin 7 (IL-)7 and stem cell factor.1 Visfatin is mainly produced in visceral white adipose tissues, and shows an insulin-like effect by binding to insulin receptors.2 Generally, visfatin is regarded as an adipokine, and elevated levels of serum visfatin in patients with type 2 diabetes,3 and obesity,4 have been reported. Interestingly, in visceral adipose tissues, macrophages seem to be the major source …

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    Footnotes

    • Competing interests: None declared.