Statistics from Altmetric.com
In a recently published study1 involving 79 ankylosing spondylitis (AS) patients and 132 unrelated healthy blood donors, Zhu et al report association of a tumour necrosis factor α (TNFα) single nucleotide polymorphism (SNP), rs1799724, with AS.1 I have many concerns with this paper and its conclusions.
The authors state that only SNP rs1799724 is not in Hardy–Weinberg equilibrium. However, inspection of the genotypes presented in table 2 of the paper reveals that rs2284178 is also not in Hardy–Weinberg equilibrium in the controls (p = 1.3×10−5). This can occur because of hidden relationship between genotyped individuals or disease association or selection, but most commonly occurs because of genotyping error. …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.