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  • A polymorphism in the gene encoding the Fcγ IIIA receptor is a possible genetic marker to predict the primary response to infliximab in Japanese patients with rheumatoid arthritis

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A polymorphism in the gene encoding the Fcγ IIIA receptor is a possible genetic marker to predict the primary response to infliximab in Japanese patients with rheumatoid arthritis
  1. S Tsukahara,
  2. K Ikari,
  3. E Sato,
  4. H Yamanaka,
  5. M Hara,
  6. T Tomatsu,
  7. S Momohara,
  8. N Kamatani
  1. Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
  1. Katsunori Ikari, MD, PhD, Institute of Rheumatology, Tokyo Women’s Medical University, 10–22 Kawada, Shinjuku, Tokyo 162-0054, Japan; kikari{at}ior.twmu.ac.jp

https://doi.org/10.1136/ard.2007.086892

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    The prediction of treatment outcome of patients with rheumatoid arthritis (RA) may avoid wasting time and cost of treatment, and allow better targeting of aggressive treatment. Recently, an amino acid-changing polymorphism in the gene encoding the Fcγ IIIA receptor (FcγRIIIA), valine (V)/phenylalanine (F) (rs396991), was found to be associated with increased likelihood of response to tumour necrosis factor (TNF)-α inhibitors in the treatment of RA.1 The aim of the present study was to determine whether this FcγRIIIA V/F polymorphism is associated with treatment outcome of infliximab (the first TNF-α inhibitor approved in Japan) in Japanese patients with RA.

    The study was approved by the Tokyo Women’s Medical University Genome Ethics Committee. The …

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    Footnotes

    • Competing interests: None.

    • Funding: Supported by grants provided by the Japan Orthopaedics and Traumatology Foundation (KI), Takeda Science Foundation (KI), and the Japanese Ministry of Education, Culture, Sports, Science and Technology (KI, ST)