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Increased blood glucose levels following intra-articular injection of methylprednisolone acetate in patients with controlled diabetes and symptomatic osteoarthritis of the knee
  1. G S Habib1,
  2. M Bashir2,
  3. A Jabbour3
  1. 1
    Rheumatology Clinic, Nazareth Hospital, Nazareth, and Department of Medicine, Carmel Medical Center, Haifa, Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
  2. 2
    Department of Medicine, Carmel Medical Center, Haifa, Israel
  3. 3
    Central Lab, Nazareth Hospital, Nazareth
  1. G S Habib, Rheumatology Clinic, Nazareth Hospital, P.O. Box 11, Nazareth 16100, Israel; gshabib62{at}

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The effect of oral or intravenous steroid treatment on glucose metabolism is well known.1 Intra-articular steroid injection (IASI) at the knee joint is a common procedure,2 however there are no studies on the effect of IASI on glucose metabolism. Patients with controlled diabetes (HgA1C<7), using modern versions of blood glucose monitoring devices, with knee pain due to osteoarthritis of the knee (OAK) for more than 3 months without sufficient response to non-steroidal anti-inflammatory drugs (NSAIDs) and physical therapy were offered an IASI of 50 mg of methylprednisolone acetate (MPA) (Pharmacia & Upjohn, Puurs, Belgium) at the knee joint. If they agreed, patients were asked to …

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  • Competing interests: None declared.

  • Ethics approval: The study was approved by the Helsinki committee of the Nazareth Hospital, and all the patients signed a consent form.

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