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Duration of pre-rheumatoid arthritis anti-cyclic citrullinated peptide positivity is positively associated with age at seroconversion
  1. W H Bos1,
  2. M M J Nielen1,
  3. B A C Dijkmans1,2,
  4. D van Schaardenburg1,2
  1. 1
    Jan van Breemen Institute, Amsterdam, The Netherlands
  2. 2
    VU University Medical Center, Department of Rheumatology, Amsterdam, The Netherlands
  1. Dr D van Schaardenburg, Department of Rheumatology, Jan van Breemen Institute, 1056 AB Amsterdam, The Netherlands; d.v.schaardenburg{at}

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Majka et al1 have recently shown that higher age at the time of diagnosis of rheumatoid arthritis (RA) is associated with an increased period of prediagnosis antibody positivity for rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP). We have extended this observation using a previously described RA cohort (n = 79) in which serial preclinical serum samples were available, in most cases preceding and following seroconversion, thereby enabling approximation of the age at seroconversion.2 A total of 32 patients were anti-CCP positive and 22 patients were IgM-RF positive in the preclinical period. The age at seroconversion and the period of seropositivity before onset of …

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  • Funding: This study was supported by the Dutch Arthritis Association.

  • Competing interests: None declared.