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Detection of latent tuberculosis in immunosuppressed patients with autoimmune diseases: performance of a Mycobacterium tuberculosis antigen-specific interferon γ assay
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  • Published on:
    The theoretical advantages of the ELISPOT assay based T-SPOT.TB test

    Dear Editor,

    After carefully reading this article and other related references, weagree that detection of M tuberculosis using interferon gamma release assays (IGRA) is more sensitive and specific than the classic Tuberculin Skin Test (TST) for the detection of Latent TB Infection (LTBI) in patients receiving immunosuppressive therapy. As the authors indicate, there are two commercially available IGRAs, an Enzyme Link...

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    Conflict of Interest:
    None declared.
  • Published on:
    PHA concentration in IGRA assays

    Dear Editor, In the article by Matulis et al, published online on 20 July 2007 the authors state in their discussion that “Compared with the ELISA test used in our study the IFN-gamma ELISPOT test was previously reported to have lower rates of indeterminate results (1). These differences may, among other reasons, be explained by differences in the concentrations of the mitogen PHA between the two test systems”. Can the authors...

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    Conflict of Interest:
    None declared.