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In the last decade it became apparent that patients with rheumatoid arthritis (RA) have an increased risk of cardiovascular disease (CVD) leading to an excess mortality of approximately 25%.1–3 Nowadays a substantial body of evidence indicates that atherosclerosis shares many features with inflammatory disease, such as RA, and that the involved inflammatory mediators are likely to be similar. More recently, evidence has emerged for the involvement of macrophage migration inhibitory factor (MIF) both in RA and atherosclerosis suggesting that MIF might form the link between RA and the increased incidence of CVD in this condition. Two known single nucleotide polymorphisms in the MIF gene have been …
Competing interests: None.
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