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Serum serotonin levels are not useful in diagnosing fibromyalgia
  1. Gabriel Jaschko1,
  2. Urs Hepp2,3,
  3. Magdalena Berkhoff2,
  4. Margrit Schmet1,
  5. Beat A Michel1,
  6. Steffen Gay1,
  7. Haiko Sprott1
  1. 1University Hospital Zurich, Department of Rheumatology and Institute of Physical Medicine, Zürich
  2. 2University Hospital Zurich, Department of Psychiatry, Zurich, Switzerland
  3. 3Psychiatrische Dienste Aargau AG, Baden, Switzerland
  1. Correspondence to:
    Haiko Sprott
    University Hospital Zurich, Department of Rheumatology and Institute of Physical Medicine, Gloriastrasse 25, CH-8091 Zürich, Switzerland; haiko.sprott{at}

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Altered concentrations of circulating serotonin have been implicated in several pathological conditions such as fibromyalgia,1–4 rheumatoid arthritis2,4,5 and major depression.6 In fibromyalgia in particular, several investigators have reported low serum serotonin levels as compared to the general population.1,3

We analysed sera from 20 patients with fibromyalgia, and compared the data with that obtained on analysis of sera from age- and gender-matched controls, including 20 patients with of rheumatoid arthritis, 20 with osteoarthritis, 20 with major depression, and 20 healthy individuals. The patients with fibromyalgia had a mean number of tender points of 16.3 and a mean duration of the disease of 9.65 years. Thirteen patients …

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  • Competing interests: None declared.