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A “new” technique for the diagnosis of chondrocalcinosis of the knee: sensitivity and specificity of high-frequency ultrasonography
  1. Georgios Filippou,
  2. Bruno Frediani,
  3. Adriana Gallo,
  4. Luana Menza,
  5. Paolo Falsetti,
  6. Fabio Baldi,
  7. Caterina Acciai,
  8. Sauro Lorenzini,
  9. Mauro Galeazzi,
  10. Roberto Marcolongo
  1. Department of Clinical Medicine and Immunological Sciences, Rheumatology Section, University of Siena, Siena, Italy
  1. Correspondence to:
    Georgios Filippou
    Department of Clinical Medicine and Immunological Sciences, Rheumatology Section, Policlinico le Scotte, viale Bracci, 53100 Siena, Italy; g_filippou{at}

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According to the criteria proposed by Ryan and McCarty,1 the diagnosis of calcium pyrophosphate dihydrate (CPPD) deposition disease has been based on radiological evidence of the characteristic calcifications and on verification of the synovial liquid of CPPD crystals.

Joint ultrasonography is an innocuous diagnostic technique that is well tolerated by patients, and is the elected method for observing calcified deposits in soft tissues.2

We carried out a longitudinal study, enrolling patients affected with ultrasonographic chondrocalcinosis according to previously proposed criteria3 from a sample of consecutive patients that came to our joint ultrasonography department for gonalgia (fig. 1). A total of 47 patients were identified, of which 14 had joint effusion.

Figure 1

 Hyperechoic deposits. Deposits (arrows) are shown that are compatible with calcium pyrophosphate dihydrate (CPPD) calcifications in the context of the synovial membrane (1), hyaline cartilage of the …

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  • Competing interests: None declared.