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- MTHFR, methylene tetrahydrofolate reductase
- MTX, methotrexate
- sHLA-G, soluble HLA-G
- SNP, single-nucleotide polymorphism
- UTR, untranslated region
We read with interest the editorial “Methotrexate pharmacogenomics” by Kremer, recently published in the Annals of Rheumatic Diseases.1 Several reports have proposed a fundamental role of the folate pathway in the clinical effects of methotrexate (MTX) treatment in rheumatoid arthritis, mainly due to genetic variations in the methylene tetrahydrofolate reductase (MTHFR) gene. The observations by Hughes et al of ethnic differences in the frequencies of single-nucleotide polymorphisms (SNPs) in the MTHFR coding region suggest possible links between other specific genotypes and MTX response.2
We recently identified an association between …
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