Background: Smoking is a well-established environmental risk factor for the development of rheumatoid arthritis (RA). However, it remains unclear whether smoking influences RA disease progression and whether smokers have more radiographic damage progression than non-smokers over time.
Objective: To compare the rates of radiographic damage progression in current smokers and non-smokers in a large prospective RA cohort.
Methods: The SCQM-RA is a population-based registry monitoring disease activity, radiographic damage and symptoms at regular intervals. All patients in the SCQM-RA database with sequential plain radiographs were included. Joint erosions were assessed in 38 hand and foot joints with a validated scoring method. The rate of erosion progression was analysed using multivariate longitudinal regression models and adjusted for potential confounders.
Results: 2004 RA patients with a mean of 3.6 sequential radiographs and 3.1 years of follow-up were included. The 545 (27%) current smokers smoked on average 16 cigarettes per day and had a mean past smoking exposure of 20.6 pack-years. Radiographic joint damage progressed at a similar rate in current smokers and non-smokers (p = 0.26). However, smoking intensity was associated with a significant inverse dose–response; heavy smokers (>1 pack-day) progressed significantly less than non-smokers or moderate smokers (p<0.001).
Conclusion: Radiographic joint damage progressed at an equivalent rate in smokers and non-smokers. Furthermore, a significant trend was observed for reduced radiographic progression and generally more favourable functional scores among heavy smokers, suggesting that cigarette smoke does not accelerate RA disease progression.
- rheumatoid arthritis
- joint damage
- environmental exposures
- HAQ, Health Assessment Questionnaire
- ICC, intraclass correlation coefficient
- RA, rheumatoid arthritis
- RF, rheumatoid factor
- SCQM-RA, Swiss Clinical Quality Management programme for RA
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Published Online First 19 January 2007
Funding: Axel Finckh is supported by a research grant from Geneva University. S. Dehler is supported by the SCQM Foundation; Karen H Costenbader is supported by an Arthritis Investigator Award from the American College of Rheumatology and the Arthritis Foundation, NIH K12 HD051959, and a Katherine Swan Ginsburg Memorial Award. C. Gabay is supported by the Swiss National Science Foundation (Grant N° 320000–107592)
Competing interests: None