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Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis
  1. J Rodriguez-Lopez1,
  2. M Pombo-Suarez1,
  3. M Liz1,
  4. J J Gomez-Reino2,
  5. A Gonzalez1
  1. 1Laboratorio de Investigacion 2 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
  2. 2Department of Medicine, University of Santiago de Compostela, Spain
  1. Correspondence to:
    Antonio Gonzalez
    Laboratorio de Investigacion 2, Hospital Clinico Universitario de Santiago, Travesia de Choupana sn, 15706-Santiago de Compostela, Spain; Antonio.Gonzalez.Martinez.Pedrayo{at}


Objective: To replicate the association of frizzled-related protein (FRZB) non-synonymous polymorphisms with osteoarthritis (OA) susceptibility.

Methods: Three groups of Spanish patients with OA were included: with total joint replacement due to primary OA in the hip (n = 310), or the knee (n = 277), or with hand OA (n = 242). Controls were more than 55 years old and did not show OA (n = 294). SNPs rs288326 (R200W) and rs7775 (R324G) were genotyped.

Results: There were no significant differences in allele frequencies between controls and each of the three groups of OA patients. However, allele G of the R324G SNP showed a trend to be more frequent in patients with a clinical OA syndrome at multiple joints (p = 0.07), specifically in women of the total hip replacement group (8.3% in patients without other affected joints, 13.1% with one, 15.9% with two and 24.1% with more than two additional joints, p for trend  = 0.008).

Conclusions: No direct replication of previous OA association findings was obtained but the results suggest that the R324G SNP of the FRZB gene may have an effect in OA development in multiple joints, with a specific severe involvement of the hip in women. This phenotype could reconcile previous studies that showed association either with generalised OA or with hip OA in women.

  • FRZB, frizzled-related protein
  • HOA, hand osteoarthritis
  • OA, osteoarthritis
  • THR, total hip replacement
  • TKR, total knee replacement

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  • Published Online First 19 January 2007

  • Funding: This project was supported by grant PI02/0713 from the Instituto de Salud Carlos III (Spain) with participation of funds from FEDER (European Union), and by the Fundacion MMA (Madrid, Spain). JR-L is the recipient of a scholarship of the Spanish Ministry of Education. MP-S received a bursary from the Fundacion Española de Reumatologia. AG was supported by the Instituto de Salud Carlos III, Spain.

  • Competing interests: None declared