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- CSF, cerebrospinal fluid
- IEF, isoelectric focusing
- OCB, oligoclonal band
- NPSLE, neuropsychiatric SLE
- SLE, systemic lupus erythematosus
Neuropsychiatric manifestations have been reported in 30–60% of patients with systemic lupus erythematosus (SLE), with variable IgG synthesis in cerebrospinal fluid (CSF).1 In this study, we sought to examine intrathecal IgG synthesis measured qualitatively as the IgG index,2 calculated using the formula
(IgG CSF/IgG serum)/(albumin CSF/albumin serum),
and quantitatively as oligoclonal bands (OCBs) by isoelectric focusing (IEF)3 in patients with SLE with various neurological presentations, and to determine the cut-off of the IgG index for the detection of these pathological IgG.
CSF results were retrieved from a database of 2902 samples using the keywords “SLE” or “lupus”. Only the first CSF sample taken before treatment for each neurological episode in each patient was analysed. Samples from …
Competing interests: None.
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