Statistics from Altmetric.com
- HLA, human leucocyte antigen
- SS, Sjögren’s syndrome
- IFN, interferon
- LSG, labial salivary gland Th1, T helper cell
- TCR, T cell receptor
Sjögren’s syndrome (SS) is a chronic autoimmune disease characterised by dry eyes, dry mouth and focal lymphocytic infiltration in lacrimal and salivary glands. The infiltrating lymphocytes are mainly CD4 α/β T cells,1 especially T helper 1 (Th1) type T cells, because they produce both interferon (IFN)γ and interleukin 2.2,3 To understand the pathogenesis of SS, several molecules in labial salivary glands (LSGs) have been screened by microarray analysis in human SS. Hjelmervik et al4 and Gottenberg et al5 reported that the upregulated genes in SS salivary glands were IFN-inducible genes, such as IFN-stimulated transcription factor 3, IFN-regulatory factor 1 and B cell-activation factor of the TNF family. …
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