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Adult-onset Still’s disease (AOSD) is characterised by a group of clinical and laboratory findings indicating systemic inflammation.1 Recent data support the hypothesis that interleukin 1 is essential in mediating inflammation, particularly in recalcitrant AOSD.2,3
From December 2003 we treated 10 patients with AOSD diagnosed according to proposed criteria.4 Four of these 10 consecutive patients, 4 had refractory AOSD with persistently active disease, despite administration of high-dose steroids. Herein, we report that all four patients rapidly responded to administration of anakinra (100 mg/day) and were promptly weaned from high-dose steroids. Table 1 shows the patients’ demographics, …
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