Statistics from Altmetric.com
The traditional treatment of systemic vasculitides with long-term oral cyclophosphamide (CPM) and high-dose corticosteroids has given way to more conservative approaches with shorter induction with CPM, followed by maintenance treatment with azathioprine or methotrexate.1 Despite this, 30–50% of patients relapse by 12 months. Endothelial dysfunction and tumour necrosis factor (TNF) α play a major part in pathogenesis.2 Raised TNF levels are associated with vascular damage and correlate with disease activity.
We describe an open-label uncontrolled prospective study of anti-TNFα (infliximab), in the management of patients with systemic vasculitides who failed to maintain remission on conventional immunosuppressive treatment.
We prospectively …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.