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Ankylosing spondylitis is a genetic-susceptible inflammatory spondyloarthropathy that mainly affects the sacroiliac joints. Tumour necrosis factor (TNF)α, a potent proinflammatory cytokine and immune modulator of joint destruction, is suggested to be a risk factor for the development of ankylosing spondylitis.1 Evidence of an association between TNFα gene polymorphisms and ankylosing spondylitis showed conflicting results. Most of such studies focused on Caucasian subjects; few in the Taiwanese population were documented except for a recent study that reported the association between the interleukin 1 gene cluster and ankylosing spondylitis.2
Our study examined the distribution of TNFα promoter polymorphisms among Taiwanese patients with ankylosing spondylitis. A total of 143 patients with ankylosing spondylitis (97 men and 46 women, mean (standard deviation (SD)) age 41.7 (11.5) years), defined by the modified …
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