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MHC2TA is associated with rheumatoid arthritis in Japanese patients
  1. Noriko Iikuni,
  2. Katsunori Ikari,
  3. Shigeki Momohara,
  4. Taisuke Tomatsu,
  5. Masako Hara,
  6. Hisashi Yamanaka,
  7. Hiroshi Okamoto,
  8. Naoyuki Kamatani
  1. Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
  1. Correspondence to:
    Dr Katsunori Ikari
    Institute of Rheumatology, Tokyo Women’s Medical University, 10–22 Kawada, Shinjuku, Tokyo 162-0054, Japan; kikari{at}

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Many diseases have increased expression of both major histocompatibility complex (MHC) class I and II molecules, and in particular the class II genes in the human leucocyte antigen region in particular are known to influence many chronic inflammatory diseases. Recently, a −168A→G polymorphism (rs3087456) in the type III promoter of MHC2TA, which has a pivotal role in MHC class II regulation, was found to be associated with increased susceptibility to rheumatoid arthritis in a Swedish population.1 However, most replication studies in other populations did not reproduce this finding, except a Spanish study.2–,6 The purpose of this study was to see if the reported association could be observed in a Japanese population.

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  • Funding: This work was supported by a grant provided by the Japan Orthopaedics and Traumatology Foundation (to KI) and a Grant-in-Aid for Young Scientists from the Japanese Ministry of Education, Culuture, Sports, Science and Technology (to KI).

  • Competing interests: None.

  • Published Online First 7 November 2006