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Many diseases have increased expression of both major histocompatibility complex (MHC) class I and II molecules, and in particular the class II genes in the human leucocyte antigen region in particular are known to influence many chronic inflammatory diseases. Recently, a −168A→G polymorphism (rs3087456) in the type III promoter of MHC2TA, which has a pivotal role in MHC class II regulation, was found to be associated with increased susceptibility to rheumatoid arthritis in a Swedish population.1 However, most replication studies in other populations did not reproduce this finding, except a Spanish study.2–,6 The purpose of this study was to see if the reported association could be observed in a Japanese population.
DNA samples …
Funding: This work was supported by a grant provided by the Japan Orthopaedics and Traumatology Foundation (to KI) and a Grant-in-Aid for Young Scientists from the Japanese Ministry of Education, Culuture, Sports, Science and Technology (to KI).
Competing interests: None.
Published Online First 7 November 2006