Article Text

Increased incidence of and impaired prognosis after acute myocardial infarction among patients with seropositive rheumatoid arthritis
  1. Anna Södergren1,
  2. Birgitta Stegmayr2,
  3. Vivan Lundberg3,
  4. Marie-Louise Öhman4,
  5. Solveig Wållberg-Jonsson1
  1. 1Department of Public Health and Clinical Medicine, Rheumatology, University Hospital, Umeå, Sweden
  2. 2Department of Public Health and Clinical Medicine, Medicine, University Hospital, Umeå, Sweden
  3. 3Department of Medicine, Kalix Hospital, Kalix, Sweden
  4. 4Department of Statistics, University of Umeå, Umeå, Sweden
  1. Correspondence to:
    A Södergren
    Department of Rheumatology, University Hospital, 901 85 Umeå, Sweden;anna.sodergren{at}


Objective: To examine the incidence and outcome of acute myocardial infarction (AMI) in patients with rheumatoid arthritis compared with the general population, and to examine whether care and treatment of an AMI differs between patients and controls.

Methods: The Multinational Monitoring of Trends and Determinants of Cardiovascular Disease register for northern Sweden was used to compare those incidences of AMI in a cohort of patients with rheumatoid arthritis with that in the general population. 35 patients with rheumatoid arthritis who had also experienced an AMI were identified. For each patient with rheumatoid arthritis, three controls with a history of AMI but without rheumatoid arthritis were randomly selected from the same register, and matched for age, sex and year of the AMI for evaluation of case fatality and potential differences in treatment of AMI.

Results: The standardised incidence ratio for AMI was 2.9 in patients with rheumatoid arthritis compared with the general population (p<0.05). During the first 10 years after an AMI, patients with rheumatoid arthritis had a higher overall case fatality compared with controls (hazard ratio (HR) 1.67, 95% confidence interval (CI) 1.02 to 2.71). Survival time was decreased in the rheumatoid arthritis group compared with controls despite the same care and treatment.

Conclusion: Both the incidence of and case fatality after an AMI were higher among patients with rheumatoid arthritis than among the general population. The results emphasise the necessity of optimising the preventive, diagnostic and caring strategies for AMI in rheumatoid arthritis.

  • AMI, acute myocardial infarction
  • CVD, cardiovascular disease
  • ECG, electrocardiogram
  • ICU, intensive care unit
  • MONICA, Multinational Monitoring of Trends and Determinants of Cardiovascular Disease
  • SIR, standardised incidence ratio

Statistics from


  • Funding: This work was supported by grants from the Swedish Research Council (K 2003-74XD-14705-01A and 345-2003-2461), the Swedish Rheumatism Association, the Swedish Heart-Lung Foundation, King Gustaf V 80th Anniversary, and King Gustaf V and Queen Viktoria Foundations, as well as the Swedish Society of Medicine.

  • Competing interests: None.

  • Ethical approval: The study was approved by the local ethics committee of Umeå University, Umeå, Sweden.

  • Published Online First 19 July 2006

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.