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Primary Sjögren’s syndrome (pSS) is a complex disease involving both genetic and environmental factors. Among the genetic susceptibility factors, HLA-DRB1 has been extensively studied as a strong candidate gene and the association of HLA-DRB1*0301 (DR3) with pSS has been frequently reported among Caucasians.1 2 As the Tumour Necrosis Factor α (TNFα) gene is located within the HLA region, its contribution to disease susceptibility has also been studied. We have previously reported a significant association of TNF-308A allele with pSS, in strong linkage disequilibrium with HLA-DRB1*03.3 This association was restricted to patients with anti-SSB antibodies. TNF exerts its action through two cell …
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