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Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial)
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  • Published on:
    Re: clinical endpoints in RA RCTs
    • Johannes W Jacobs, Rheumatologist
    • Other Contributors:
      • Suzan MM Verstappen, Johannes JW Bijlsma

    Dear Editor,

    We do thank Maarten Boers for his complement. We did not employ the composite indices DAS or DAS28 to report clinical efficacy of the two strategy groups in our study, because we had used joint counts not including shoulder joints, which precludes calculating these indices. In our view, shoulder joints are seldom involved in early rheumatoid arthritis and are in addition difficult to score for swelling....

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    Conflict of Interest:
    None declared.
  • Published on:
    clinical endpoints in RA RCTs

    Dear Editor, Verstappen et al are to be congratulated on their 'CAMERA' strategy trial. However, they have chosen not to report the results expressed in the Disease Activity Score (DAS or DAS28). In addition, the international RA core set agreed to in 1992 was not fully applied because physician global assessment was not measured. This is a pity because it precludes calculation of ACR reponse. The lack of both DAS and ACR re...

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    Conflict of Interest:
    None declared.