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A novel gene variation of TNFα associated with ankylosing spondylitis: a reconfirmed study
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  • Published on:
    Genetic Variability Could Be Confusing SNP Studies in AS

    Dear Editor,

    It is with great interest that I read the study entitled "A novel gene variation of TNF associated with ankylosing spondylitis: a reconfirmed study" by Zhu et al(1). In treating AS in Los Angeles, California, I see many Hispanic patients especially from Mexican descent. This is very different from the Chinese population presented in this article and may explain some of the difficulties in looking for SNP'...

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    Conflict of Interest:
    None declared.
  • Published on:
    TNFA variants and Ankylosing Spondylitis

    Dear Editor,

    In a study recently published in Annals of the Rheumatic Diseases involving 79 ankylosing spondylitis (AS) patients and 132 unrelated healthy blood donors, Zhu and colleagues report association of a TNFA SNP, rs1799724, with AS [1]. I have many concerns with this paper and its conclusions.

    The authors state that only SNP rs1799724 is not in Hardy-Weinberg equilibrium. However, inspection of the ge...

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    Conflict of Interest:
    None declared.