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Obestatin is a 23 amino acid amidated peptide identified as the product of posttranslational cleavage of the preproghrelin,1 the polypeptide precursor of ghrelin. Obestatin has been reported to have actions opposite to ghrelin,2 but its ghrelin antagonist properties are still unclear and controversial. As our group has identified ghrelin as a peptide synthesised and secreted by chondrocytes, with significant biological activity on cartilage cell metabolism,3 it was conceivable that obestatin might exert some physiological action on chondrocytes. These cells are emerging as a local producer and target of several endocrine factors including ghrelin3 and leptin.4 5 It is of note that the obestatin co-joined hormone ghrelin has been revealed as a convergent factor between bone metabolism and energy homeostases.6 7 So, it was plausible to verify the …
The research described in this article has been supported by the Spanish Ministry of Health, Fondo de Investigación Sanitaria, Instituto de Salud Carlos III (FIS PI 05/0525, PI030115, PI050419) and Xunta de Galicia. O.G. and F.L. are recipients of a contract under the “Programme of stabilization of researchers” co-funded by the Instituto de Salud Carlos III and SERGAS. R.L. and R.G. are recipients of a project-associated fellowship from Instituto de Salud Carlos III.