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Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterised by an unknown inflammatory process in multiple joints. The K/BxN T cell receptor transgenic mouse model is a striking model of inflammatory arthritis characterised by arthritic manifestations similar to those of RA.1 Matsumoto et al reported that arthritis could be provoked by linked T and B cell recognition of a ubiquitously expressed self antigen glucose-6-phosphate isomerase (GPI).2 Recently, immunisation with recombinant human GPI was reported to induce T cell dependent arthritis in DBA/1 mice,3 supporting the notion that GPI reactive T cells have a crucial role in the induction of arthritis.
In our previous study we reported the presence of high titres of anti-GPI antibodies (Abs) in some patients with RA, although a few control subjects were also positive.4 To examine the role of GPI-specific T cells in patients …
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