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Prevalence of an abnormal ankle-brachial index in patients with antiphospholipid syndrome with pregnancy loss but without thrombosis: a controlled study
  1. C Christodoulou,
  2. M Zain,
  3. M L Bertolaccini,
  4. S Sangle,
  5. M A Khamashta,
  6. G R V Hughes,
  7. D P D’Cruz
  1. The Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, UK
  1. Correspondence to:
    Dr D P D’Cruz
    The Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, SE1 7EH, UK; david.d’cruz{at}

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The antiphospholipid syndrome (APS) is characterised by recurrent arterial or venous thromboembolism, or pregnancy loss, in association with antiphospholipid antibodies.1 The pathogenesis of the obstetric complications remains unclear—both antiphospholipid antibodies and atherosclerosis may have a role. The ankle-brachial index (ABI) is a bedside test which reliably identifies lower extremity peripheral artery disease in asymptomatic people.2 Our hypothesis was that a diffuse vessel wall abnormality as detected by the ABI might be associated with the pregnancy morbidity in patients with APS. We studied patients with APS with previous pregnancy loss but no thrombosis and compared their ABI and vascular risk factors with those of healthy women. The study was approved by the ethics committee.

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