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Single nucleotide polymorphisms in the gene encoding the major histocompatibility complex class II transactivator (CIITA) in systemic lupus erythematosus (Koizumi K, Okamoto H, Iikuni N, Nakamura T, Kawamoto M, Momohara S, Ichikawa N, Furuya T, Kotake S, Taniguchi A, Yamanaka H, Kamatani N. Ann Rheum Dis 2005;64:947–50.)

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Figure 1

 SNPs in MHC2TA pIII and coding region. (A) Genomic DNA was isolated from peripheral blood mononuclear cells, and PCR and direct sequencing were performed with eight oligonucleotide primer sets for genomic analysis of SNPs (arrows). (B) MHC2TA promoter elements and exon organisation. Arrows on the box represent upstream regulatory sequences for each promoter. Promoter pI is used primarily by dendritic cells, pIII by B cells, and pIV for IFNγ-inducible CIITA expression by non-professional APCs.

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