Article Text

Download PDFPDF
Antibodies to α-fodrin derived peptide in Sjögren’s syndrome
  1. J He,
  2. Q L Chen,
  3. Z G Li
  1. Department of Rheumatology and Immunology, People’s Hospital, Peking University, 11 Xizhimen South St, Beijing 100044, China
  1. Correspondence to:
    Dr Z G Li

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Sjögren’s syndrome (SS) is a chronic autoimmune disorder of unknown cause. Haneji et al identified a 120 kDa fragment of the ubiquitous cytoskeletal protein α-fodrin as an autoantigen in an NFS/sld mouse model of human SS.1 More recently, the sensitivity and specificity of α-fodrin antibodies in SS in several studies suggested that it might be of value in the diagnosis of SS.1–3 In the present study, a conserved motif, rather than the whole protein, in α-fodrin was used as antigenic peptide to define further the role of anti-α-fodrin antibodies in SS. This is the first study so far to evaluate the prevalence of anti-α-fodrin peptide antibodies (α-FPA) in a cohort of Chinese patients with SS.

Serum samples from 89 patients with SS (85 female, 4 male; 74 with primary SS (pSS) and 15 with …

View Full Text


  • Competing interest: None.