Statistics from Altmetric.com
Signaling lymphocytic activation molecule family member 1 (SLAMF1) is a member of the CD2 immunoglobulin superfamily, which is expressed in T cells, B cells, macrophages and dendritic cells.1SLAMF1 is associated with B cell proliferation and immunoglobulin synthesis.2 The expression of SLAMF1 in peripheral blood B cells from patients with rheumatoid arthritis was raised compared with healthy controls,3 and high expression of this molecule was observed in synovial fluid and tissue of patients with rheumatoid arthritis. Moreover, mice deficient in the SH2D1A molecule, which binds to the SLAMF1 receptor, were susceptible to experimental autoimmune diseases.4,5 Considering these biological data and the potential role of the SLAMF1 gene in regulating the immune system, we investigated the candidate gene SLAMF1 polymorphism, located on chromosome …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.